BI-0115
目录号 : KE9788
CAS No. : 4929-23-1
纯度 : ≥95%
BI-0115 is a selective small molecule inhibitor of LOX-1 that blocks cellular uptake of oxLDL. It binding triggers receptor inhibition by formation of dimers of the homodimeric ligand binding domain. The structure of LOX-1 bound to BI-0115 shows that inter-ligand interactions at the receptor interfaces are key to the formation of the receptor tetramer thereby blocking oxLDL binding.
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生物活性 |
BI-0115 is a selective small molecule inhibitor of LOX-1 that blocks cellular uptake of oxLDL. It binding triggers receptor inhibition by formation of dimers of the homodimeric ligand binding domain. The structure of LOX-1 bound to BI-0115 shows that inter-ligand interactions at the receptor interfaces are key to the formation of the receptor tetramer thereby blocking oxLDL binding.
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分子式 |
C15H14ClN3O
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分子量 |
287.75
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CAS号 |
4929-23-1
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中文名称 |
BI-0115
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运输条件 |
Room temperature in continental US; may vary elsewhere.
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储存方式 |
Store at -20˚C
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