| 生物活性 |
GDC-0575 is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2 nM. GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases, which permits the cells to undergo DNA repair prior to entry into mitosis.
|
|---|---|
| 分子式 |
C16H21BrClN5O
|
| 分子量 |
414.73
|
| CAS号 |
1196504-54-7
|
| 中文名称 |
N-[4-[（3R）-3-氨基哌啶-1-基]-5-溴-1H-吡咯[2,3-b]吡啶-3-基]环丙烷甲酰胺
|
| 运输条件 |
Room temperature in continental US; may vary elsewhere.
|
| 储存方式 |
Store at -20˚C
|
纯度： ≥95%
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