Belotecan hydrochloride (CKD-602 hydrochloride), a Topoisomerase I inhibitor, is a synthetic camptothecin derivative.
IC50&Target
Top1
体外研究
Belotecan exerts a significant cytotoxic effect on YD-8, YD-9 and YD-38 cells in a time- and dose-dependent manner with IC50 values of 2.4, 0.18 and 0.05 μg/mL at 72 h following treatment. Belotecan induces apoptosis in these cell lines. Belotecan induces G2/M phase arrest in oral squamous cell cancer cells. Belotecan shows a significant anticancer effect on glioma cells, with IC50 values of 9.07 nM for LN229, 14.57 nM for U251 MG, 29.13 nM for U343 MG, and 84.66 nM for U87 MG.
体内研究
Belotecan has a significant effect on intracerebral glioma growth, with animals having significantly smaller tumors than those in the control group.
分子式
C25H28ClN3O4
分子量
469.96
CAS号
213819-48-8
中文名称
盐酸贝洛替康
运输条件
Room temperature in continental US; may vary elsewhere.