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TA-3166 (Megakaryocytes/platelets inducing agent) is a novel chemically synthesized c-MPL agonist (CMA) and thrombopoietin (TPO) receptor agonist. TA-316 enhances ex vivo platelet generation from human-induced pluripotent stem (iPS) cells.

TA-316 (0.01-1000 nM; 4 days) stimulates UT-7/TPO and Ba/F3-HuMpl cells proliferation, with the EC₅₀ values of 0.3 and 0.65 nM, respectively.
TA-316 (800 nM; 10 days) promotes biased megakaryopoiesis and upregulated MK lineage markers.
TA-316 (200 nM; 4 days) preferentially enhances VEGFA and FGF2 expression.

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