NMS-873 is a potent, selective allosteric VCP/p97 inhibitor with an IC50 value of 30 nM.
IC50&Target
IC50: 30 nM
体外研究
NMS-873 has antiproliferative effect on a panel of tumor cell lines with IC50 values in the range of 0.08 μM to 2 μM. For HCT116 and HeLa cells, the IC50 values are 0.4 μM and 0.7 μM, respectively. NMS-873 reduces VCP sensitivity to trypsin digestion, preventing degradation of the linker-D2 domain. NMS-873 induces clear, dose-dependent accumulation of poly-Ub proteins and stabilization of cyclin E and Mcl-1 at doses consistent with its antiproliferative IC50 value.
分子式
C27H28N4O3S2
分子量
520.67
CAS号
1418013-75-8
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder
-20°C
3 years
4°C
2 years
In solvent
-80°C
6 months
-20°C
1 month
溶解性数据
In Vitro:
DMSO : 20.5 mg/mL (39.37 mM; Need ultrasonic and warming)