TAS4464 is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE), with an IC50 of 0.955 nM.
IC50&Target
IC50:0.955 nM (NAE)
体外研究
TAS4464 treatment inhibits cullin neddylation and subsequently induces the accumulation of CRL substrates such as CDT1, p27, and phosphorylates IκBα in 47 human cancer cell lines.
分子式
C21H23FN6O6S
分子量
506.51
CAS号
1848959-10-3
运输条件
Room temperature in continental US; may vary elsewhere.