IWP-O1 is a highly potent Porcupine (Porcn) inhibitor, with an EC50 of 80 pM in L-Wnt-STF cells. IWP-O1 prevents the secretion of Wnt proteins. IWP-O1 suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.
IC50&Target
EC50: 80 pM (Porcn).
体外研究
IWP-O1 (17) suppresses Wnt signaling in L-Wnt-STF cells with an EC50 value of 80 pM, 2.5 times more active than the investigational drug LGK974.
分子式
C26H20N6O
分子量
432.48
CAS号
2074607-48-8
运输条件
Room temperature in continental US; may vary elsewhere.