Amifostine thiol - CAS:31098-42-7

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Amifostine thiol (Synonyms:WR-1065)

目录号 : KM8509 CAS No. : 31098-42-7

Data Sheet 产品使用指南

Amifostine thiol (WR-1065) 是细胞保护剂 Amifostine 的活性代谢物。Amifostine thiol 是一种具有辐射防护能力的细胞保护剂。Amifostine thiol 通过 JNK 依赖的信号通路激活 p53。

规格	价格	是否有货
10mg		In-stock
50mg	询价	In-stock
100mg	询价	In-stock

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生物活性

Amifostine thiol (WR-1065) is an active metabolite of the cytoprotector Amifostine . Amifostine thiol is a cytoprotective agent with radioprotective abilities. Amifostine thiol activates p53 through a JNK-dependent signaling pathway.

体外研究

Amifostine thiol can reduce both the direct and delayed detrimental effects of both high and low-LET radiation exposures.
Amifostine thiol attenuates both the DNA damage and the G1-phase arrest induced by radiation.
Amifostine thiol (4 mM; 30 minutes) protects RKO36 cells from chromosomal damage and death induced by ionizing radiation.
Amifostine thiol (4 mM; 30 minutes) protects irradiated RKO36 cells from delayed genomic instability.
Amifostine thiol is cytotoxic to RKO36 cells at milimolar concentrations, especially after continuous treatment.
Amifostine thiol at 40 μM protects RKO36 cells from delayed genomic instability but not from cell death and immediate chromosomal damage.
Amifostine thiol activates JNK resulting in the phosphorylation of p53 at threonine 81.
Amifostine thiol affects phosphorylation of topoisomerase IIα leading to changes in enzyme activity and cell cycle progression in CHO AA8 cells.

分子式

C₅H₁₄N₂S

分子量

134.24

CAS号

31098-42-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

溶解性数据

In Vitro:

DMSO : 250 mg/mL (1862.34 mM; Need ultrasonic)

H₂O : 100 mg/mL (744.93 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	7.4493 mL	37.2467 mL	74.4934 mL
5 mM	1.4899 mL	7.4493 mL	14.8987 mL
10 mM	0.7449 mL	3.7247 mL	7.4493 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

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