ABT-100
目录号 : KM8328 CAS No. : 450839-40-4 纯度 : 98%

ABT-100 是一种有效的,高选择性和口服活性的 farnesyltransferase 抑制剂。ABT-100 抑制细胞增殖 (对于 EJ-1,DLD-1,MDA-MB-231,HCT-116,MiaPaCa-2,PC-3 和 DU-145 细胞的 IC50 分别为 2.2 nM,3.8 nM,5.9 nM,6.9 nM,9.2 nM,70 nM 和 818 nM),可增加细胞凋亡并减少血管生成。ABT-100 具有广谱抗肿瘤活性。

规格 价格 是否有货 数量
5mg
In-stock
10mg 询价 In-stock
50mg 询价 In-stock

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生物活性

ABT-100 is a potent, highly selective and orally active farnesyltransferase inhibitor. ABT-100 inhibits cell proliferation (IC50s of 2.2 nM, 3.8 nM, 5.9 nM, 6.9 nM, 9.2 nM, 70 nM and 818 nM for EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells, respectively), increases apoptosis and decreases angiogenesis. ABT-100 possesses broad-spectrum antitumor activity.

体外研究

ABT-100 (0.1-100 nM; 7 days; EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells) treatment shows dose-dependent growth inhibition of human cancer cell lines. Also inhibits colony formation at concentrations comparable with which ABT-100 inhibits anchorage-dependent growth.

Cell Proliferation Assay

Cell Line: EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells
Concentration: 0.1-100 nM
Incubation Time: 7 days
Result: Demonstrated dose-dependent growth inhibition of human cancer cell lines.
体内研究

ABT-100 (6.25-12.5 mg/kg/day; subcutaneous injection; daily; for 21 days; C.B-17 scid male mice) treatment regresses EJ-1 tumors in mice.

Animal Model: C.B-17 scid male mice with EJ-1 cells
Dosage: 6.25 mg/kg/day, 12.5 mg/kg/day
Administration: Subcutaneous injection; daily; for 21 days
Result: Regressed EJ-1 tumors in C.B-17 scid male mice.
分子式
C27H19F3N4O3
分子量
504.46
CAS号
450839-40-4
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
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