3,6-DMAD dihydrochloride - CAS:2226511-77-7

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3,6-DMAD dihydrochloride

目录号 : KM24593 CAS No. : 2226511-77-7 纯度 : 98%

Data Sheet 产品使用指南

3,6-DMAD dihydrochloride, an acridine derivative, is a potent IRE1α-XBP1s pathway inhibitor. 3,6-DMAD dihydrochloride promotes IL-6 secretion via the IRE1α-XBP1s pathway. 3,6-DMAD dihydrochloride inhibits IRE1α oligomerization and endoribonuclease (RNase) activity. 3,6-DMAD dihydrochloride can be used for research of cancer.

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50mg	询价	In-stock
100mg	询价	In-stock
250mg	询价	In-stock

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Other Forms of Rapamycin:

3,6-DMAD dihydrochloride In-stock
IRE1α kinase-IN-2 In-stock
3,6-DMAD hydrochloride In-stock
GSK2850163 In-stock
APY29 In-stock

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生物活性

体外研究

3,6-DMAD dihydrochloride (0-6 μM; 24 h; RPMI 8226 and MM1.R human MM cells) has cytotoxicity against MM cell lines.
3,6-DMAD dihydrochloride (0-30 μM; 14 h; HT1080 cells treated with Tg (0.3 μM)) inhibits XBP1 splicing (XBP1s) in a dose dependent manner.
3,6-DMAD dihydrochloride (0.1-500 μM; 14 h; HT1080 cells treated with Tg (0.3 μM)) inhibits IRE1α endonuclease activity.
3,6-DMAD dihydrochloride (1-60 μM; 2 h; HEK293 cells) inhibits IRE1α oligomerization and IRE1α-GFP foci formation.

Cell Viability Assay

Cell Line:

RPMI 8226 and MM1.R human MM cells

Concentration:

0, 0.5, 1, 2, 3, 4, 5 and 6 μM

Incubation Time:

24 hours

Result:

Inhibited cell survival rate in a dose dependent manner.

Cell Viability Assay

Cell Line:

0, 5, 10 and 30 μM

Concentration:

0, 0.5, 1, 2, 3, 4, 5 and 6 μM24 hours

Incubation Time:

14 hours

Result:

Showed XBP1s inhibition at as low as 0.5 μM.

体内研究

3,6-DMAD dihydrochloride (10 mg/kg; i.p.; three times every 12 hours, for 84 hours; NOD Scid mice with RPMI 8226 xenograft) has inhibition of XBP1 splicing in vivo.
3,6-DMAD dihydrochloride (10 mg/kg; 24 h; i.p.; every 48 hours, for 12 days; NOD Scid mice with RPMI 8226 xenograft) suppresses multiple myeloma xenograft growth in vivo.

Animal Model:	NOD Scid mice (4-6 weeks) with RPMI 8226 xenograft
Dosage:	10 mg/kg
Administration:	Intraperitoneal injection; three times every 12 hours, for 84 hours
Result:	Inhibited XBP1-luciferase activity in NOD Scid mice with RPMI 8226 xenograft.

Animal Model:	NOD Scid mice (4-6 weeks) with RPMI 8226 xenograft
Dosage:	10 mg/kg
Administration:	Intraperitoneal injection; every 48 hours, for 12 days
Result:	Inhibited tumor growth in NOD Scid mice with RPMI 8226 xenograft.

分子式

C₂₂H₃₃Cl₂N₅

分子量

438.44

CAS号

2226511-77-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

纯度： 98%

Data Sheet

产品使用指南

Jiang D, et, al. Acridine Derivatives as Inhibitors of the IRE1α-XBP1 Pathway Are Cytotoxic to Human Multiple Myeloma. Mol Cancer Ther. 2016 Sep;15(9):2055-65.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

体积

分子量*

重置计算

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

重置计算

动物实验计算换算器

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系客服为您提供正确的澄清溶液配方）

% DMSO

% Tween 80

% ddH₂O

% DMSO

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系客服）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

配置后的溶液总体积：

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

Other Forms of Rapamycin:

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The molarity calculator equation

The dilution calculator equation

动物实验计算换算器