Cabozantinib-d6 (XL184-d6) 是 Cabozantinib 的氘代物。Cabozantinib是一种有效的多受体酪氨酸激酶抑制剂， 抑制VEGFR2，c-Met，Kit，Axl 和 Flt3 的 IC50 分别为0.035，1.3，4.6，7 和 11.3 nM。
| 生物活性 |
Cabozantinib-d6 (XL184-d6) is the deuterium labeled Cabozantinib. Cabozantinib is a potent multiple receptor tyrosine kinases (RTKs) inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50s of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively. |
|---|---|
| 体外研究 |
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. |
| 分子量 |
507.54
|
| CAS号 |
1802168-46-2
|
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
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