SR0987, a SR1078 analog, is a RORγt agonist, with an EC50 of 800 nM. SR0987 increases IL17 expression while repressing the expression of PD-1.
IC50&Target
EC50: 800 nM (RORγt).
体外研究
SR0987 clearly shows a concentration dependent induction of reporter gene expression with an EC50 of ~800nM. SR0987 treatment results in a statistically significant reduction of the surface expression of PD-1 whereas desmostrol treatment shows no effect. Treatment with SR0987 and or desmosterol results in a trend towards increased IL17 production.
分子式
C16H10NO2F6Cl
分子量
397.70
CAS号
303126-97-8
运输条件
Room temperature in continental US; may vary elsewhere.