(Rac)-Idroxioleic acid - CAS:56472-29-8

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(Rac)-Idroxioleic acid (Synonyms:2-Hydroxyoleic acid; 2-OHOA)

目录号 : KM7934 CAS No. : 56472-29-8 纯度 : ≥98%

Data Sheet SDS 产品使用指南

(Rac)-Idroxioleic acid (2-Hydroxyoleic acid) 是一种合成油酸 (OA) 衍生物，能与质膜结合改变脂质组织。(Rac)-Idroxioleic acid 具有抗肿瘤作用。

规格	价格	是否有货
5mg		In-stock
10mg		In-stock
50mg	询价	In-stock
100mg	询价	In-stock

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生物活性

(Rac)-Idroxioleic acid (2-Hydroxyoleic acid) is a synthetic oleic acid (OA) derivative that binds to the plasma membrane and alters lipid organization. (Rac)-Idroxioleic acid has anti-tumor effect.

体外研究

(Rac)-Idroxioleic acid (25-75 μM; 72 hours) impairs Jurkat cell growth in a time- and concentration-dependent manner, with an IC₅₀ of ~40 μM.
(Rac)-Idroxioleic acid (25-50 μM; 72 hours) also induces a marked and concentration-dependent increase in the proteolytic cleavage of PARP, a molecular marker of apoptosis.

Cell Viability Assay

Cell Line:	Jurkat cells
Concentration:	25 μM, 50 μM, 75 μM
Incubation Time:	24 hours, 48 hours, 72 hours
Result:	Impaired Jurkat cell growth in a time- and concentration-dependent manner.

Western Blot Analysis

Cell Line:	Jurkat cells
Concentration:	25 μM, 50 μM
Incubation Time:	72 hours
Result:	Induced a marked and concentration-dependent increase in the proteolytic cleavage of PARP.

体内研究

(Rac)-Idroxioleic acid markedly and significantly inhibits tumour growth in nude mice infected with Jurkat cells.

Animal Model:	6-week-old nude male mice (Jurkat cells xenograft model)
Dosage:	600 mg/kg
Administration:	Oral administration; daily; for 21 days
Result:	Markedly and significantly inhibited tumour growth.

分子式

C₁₈H₃₄O₃

分子量

298.46

CAS号

56472-29-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

临床试验

纯度： ≥98%

Data Sheet

SDS

产品使用指南

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

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浓度

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动物实验计算换算器

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

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第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系客服为您提供正确的澄清溶液配方）

% DMSO

% Tween 80

% ddH₂O

% DMSO

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计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系客服）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

配置后的溶液总体积：

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

Other Forms of Rapamycin:

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The molarity calculator equation

The dilution calculator equation

动物实验计算换算器