GNE-495 is a potent and selective MAP4K4 inhibitor with an IC50 of 3.7 nM.
体外研究
GNE-495 is a potent and selective MAP4K4 inhibitor with efficacy in retinal angiogenesis. GNE-495 shows the best balance of MAP4K4 inhibition, permeability, microsomal stability, and cellular potency.
体内研究
GNE-495 is administered intraperitoneally to neonatal mouse pups at high doses: 25 and 50 mg/kg. GNE-495 shows good in vivo profile in all species tested, with low clearances, moderate terminal half-lives, and reasonable oral exposure levels (F=37-47%).
分子式
C22H20FN5O2
分子量
405.42
CAS号
1449277-10-4
运输条件
Room temperature in continental US; may vary elsewhere.