StemRegenin 1 是一种有效的芳香烃受体 (AhR) 拮抗剂，IC50 为 127 nM。
| 生物活性 |
StemRegenin 1 is a potent aryl hydrocarbon receptor (AhR) antagonist with IC50 of 127 nM. |
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| 体外研究 |
StemRegenin 1 (SR1) acts by antagonizing the aryl hydrocarbon receptor (AhR). StemRegenin 1 increases the number of CD34 cells after 5 to 7 days with an EC50 of ~120 nM. StemRegenin 1 inhibits photoaffinity ligand (PAL) binding (IC50=40 nM) These results support the conclusion that StemRegenin 1 -induced CD34 cell expansion is mediated through direct binding and inhibition of the AhR. An aryl hydrocarbon receptor antagonist, StemRegenin 1 (SR1), robustly promotes ex vivo expansion of human CD34 cells. StemRegenin 1 treatment accelerates the proliferation of CD34 cells and decreases the expression levels of VentX. |
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| 分子式 |
C24H23N5Os
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| 分子量 |
429.54
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| CAS号 |
1227633-49-9
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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| 临床试验 |
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| 科研文献 |
纯度： 98%
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