CCR7 Ligand 1 - CAS:681514-83-0

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CCR7 Ligand 1 (Synonyms:CCR7-Cmp2105)

目录号 : KM7301 CAS No. : 681514-83-0 纯度 : 98%

Data Sheet 产品使用指南

CCR7 Ligand 1 (CCR7-Cmp2105) 是人 CC 趋化因子受体 7 (CCR7) 的变构配体，也是有效的 CCR7 拮抗剂，K_d 值为 3 nM。CCR7 Ligand 1 是一种噻二唑-二氧化物配体，可抑制蛋白与 CCL19 激活反应结合，IC₅₀ 为 7.3 μM。

规格	价格	是否有货
5mg		In-stock
10mg		In-stock
50mg		In-stock
100mg	询价	In-stock
200mg	询价	In-stock

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生物活性

CCR7 Ligand 1 (CCR7-Cmp2105) is an allosteric Ligand and antagonist for human CC chemokine receptor 7 (CCR7) with a K_d of 3 nM. CCR7 Ligand 1, thiadiazole-dioxide ligan, suppresses arrestin binding in response to activation by CCL19 with an IC₅₀ of 7.3 μM.

体外研究

CCR7 Ligand 1 (CCR7-Cmp2105) binds to a pocket at the intracellular part of CCR7 between the ends of TM1, TM2, TM3, and TM6 and the loop between TM7 and H8.
CCR7 Ligand 1 allosterically inhibits binding of the native chemokine CCL19 ligand in scintillation proximity assays (bottom) with an IC50 of 35 nM.
CCR7 Ligand 1 (20, 40, 60, 80, 100 μM) has dose-dependent thermo-stabilizing effect on CCR7.

分子式

C₂₂H₂₉N₅O₅S

分子量

475.56

CAS号

681514-83-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性数据

In Vitro:

DMSO : 100 mg/mL (210.28 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.1028 mL	10.5139 mL	21.0278 mL
5 mM	0.4206 mL	2.1028 mL	4.2056 mL
10 mM	0.2103 mL	1.0514 mL	2.1028 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： 98%