BAY885 is a highly potent and selective ERK5 inhibitor with an IC50 of 35 nM. BAY885 shows weak inhibition on others kinases.
IC50&Target
ERK5
35 nM (IC50)
体外研究
The ERK5 probe 41 (BAY-885) showed potent ERK5 kinase and transcriptional inhibition in the SN12C-MEF2 reporter cell line (IC50 = 115 nM/IC90 = 691 nM) and had no effects on a reporter control cell line with constitutive luciferase expression (SN12C-CMV-luc, IC50 > 30 μM).
分子式
C25H28F3N7O2
分子量
515.53
CAS号
2307249-33-6
运输条件
Room temperature in continental US; may vary elsewhere.