GSK3145095 is a RIP1 kinase inhibitor with an IC50 of 6.3 nM .
IC50&Target
IC50: 6.3 nM (RIP1 kinase )
体外研究
GSK3145095 potently blocks the TNF response as shown by determination of overall cell viability as measured by cellular ATP levels (IC50 = 1.6 nM), cell death as measured by LDH release (IC50 = 0.5 nM) and RIP1-dependent inflammatory cytokine MIP-1β production, either as absolute levels for protein, or fold changes in mRNA expression (IC50 = 0.4 nM) .
分子式
C20H17F2N5O2
分子量
397.38
CAS号
1622849-43-7
运输条件
Room temperature in continental US; may vary elsewhere.