5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase, with IC50s of 9, 20 and 25 nM, respectively.
IC50&Target
GSK-3β
9 nM (IC50)
Cdk5/p25
20 nM (IC50)
Cdk1/cyclin B
25 nM (IC50)
分子式
C16H10N3O2I
分子量
403.17
CAS号
331467-03-9
运输条件
Room temperature in continental US; may vary elsewhere.