Gboxin is an oxidative phosphorylation (OXPHOS) inhibitor that targets glioblastoma. Gboxin inhibits the activity of F0F1 ATP synthase. Antitumour activity.
IC50&Target
F0F1 ATP synthase
体外研究
Gboxin (0-15 μM; 96 hours) specifically inhibit the growth of primary ‘high-throughput GBM sphere’ (HTS) cells but not that of cycling primary low-passage mouse embryonic fibroblasts (MEFs) or astrocytes.
Cell Viability Assay
Cell Line:
HTS cells, MEFs and astrocytes
Concentration:
0, 185, 555, 1667, 5000, 15000 nM
Incubation Time:
96 hours
Result:
Inhibited the growth of HTS cells (IC50=150 nM).
分子式
C22H34ClN2O2
分子量
392.96
CAS号
2101315-36-8
运输条件
Room temperature in continental US; may vary elsewhere.