BX517 is a potent and selective inhibitor of PDK1 with IC50 of 6 nM.
IC50&Target
IC50: 6 nM (PDK1)
体外研究
BX-517 blocks activation of Akt in tumor cells, is potent with IC50 of 0.1-1.0 μM. BX-517 blocks AKT2 activation in cells with submicromolar potency. BX-517 is 100-fold selective or better against a panel of seven additional Ser/Thr and Tyr kinases.
分子式
C15H14N4O2
分子量
282.30
CAS号
850717-64-5
运输条件
Room temperature in continental US; may vary elsewhere.