BDP9066 是肌强直性肌营养不良相关 Cdc-42 结合激酶 MRCK 的选择性有效抑制剂，其在 SCC12 细胞中测得对 MRCKβ 的IC50 值为 64 nM，对 MRCKα/β 的 Ki 值分别为 0.0136 nM 和 0.0233 nM。BDP9066 可用来研究皮肤癌。
| 生物活性 |
BDP9066 is a potent and selective myotonic dystroprelated Cdc42-binding kinase MRCK inhibitor with an IC50 of 64 nM for MRCKβ in SCC12 cells, Ki values of 0.0136 nM and 0.0233 nM for MRCKα/β in house determinations, respectively. BDP9066 has therapeutic effect on skin cancer by reducing substrate phosphorylation. |
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| 体外研究 |
BDP9066 shows antiproliferative effects with greatest activity in hematologic cancer cells. BDP9066 inhibits MLC phosphorylation and blocks SCC12 squamous cell carcinoma motility and invasion. |
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| 体内研究 |
BDP9066 topical application significantly decreases phosphorylated MRCKα S1003 staining and tumor volumes.
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| 分子式 |
C20H24N6
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| 分子量 |
348.44
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| CAS号 |
2226507-04-4
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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纯度： 98%
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