BMS-794833 is a VEGFR2 and Met inhibitor extracted from patent WO2009094417, compound example 1; has IC50s of 15 and 1.7 nM, respectively.
IC50&Target
VEGFR2
15 nM (IC50)
Met
1.7 nM (IC50)
体外研究
BMS794833 inhibits Met receptor activated gastric carcinoma cell line, GTL-16, with an IC50 of 39 nM.
体内研究
BMS-794833 is active by greater than 50% tumor growth inhibition for at least one tumor doubling time in the GTL-16 gastric carcinoma model. No toxicity is observed at any of the dose levels when administered once daily for a duration of 14 days.
分子式
C23H15ClF2N4O3
分子量
468.84
CAS号
1174046-72-0
运输条件
Room temperature in continental US; may vary elsewhere.