ALK inhibitor 2 (compound 18) is a potent pyrimidin ALK inhibitor. ALK inhibitor 2 is a potent inhibitor of testis-specific serine/threonine kinase 2 (TSSK2; IC50=37 nM) and focal adhesion kinase (FAK; IC50=5 nM).
IC50&Target
IC50: 37 nM (TSSK2) and 5 nM (FAK)
体外研究
Testis-specific serine/threonine kinase 2 (TSSK2) is an important target for reversible male contraception. ALK inhibitor 2 (compound 18) contains a methylpiperazine A ring (R1=Me, X=N) and a D ring with R5=methylsulfonamide. ALK inhibitor 2 can undergo metabolic oxidation to form reactive adducts in the presence of glutathione.
分子式
C23H28ClN7O3S
分子量
518.03
CAS号
761438-38-4
运输条件
Room temperature in continental US; may vary elsewhere.