CM-579 trihydrochloride is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells.
IC50&Target
DNA Methyltransferase
32 nM (IC50)
DNMT1
1.5 nM (Kd)
DNMT3A
92 nM (IC50)
DNMT3B
1000 nM (IC50)
G9a
16 nM (IC50)
体外研究
The Kd of CM-579 for DNMT1 is 1.5 nM, CM-579 also inhibits DNMT3A and DNMT3B, with IC50s of 92 nM and 1000 nM, respectively.
运输条件
Room temperature in continental US; may vary elsewhere.