AZD7507 is a potent and orally active CSF-1R inhibitor, with antitumor activity.
体外研究
AZD7507 (Compound 31) inhibits the proliferation of 3T3 cells engineered to express CSF-1R and stimulated with CSF-1 (IC50, 32 nM), shows inhibitory activity against hERG and NaV1.5, with IC50s of >30 and 26 μM.
体内研究
AZD7507 has good rat oral PK, with in vivo clearance of 7 mL/min/kg and 42% bioavailability. In the canine L-type Ca channel assay, the IC50 is >20 μM. AZD7507 significantly decreases the number of CD68 macrophages in mice, and also reduces the volume and mass in mice bearing CC-LP-1 and SNU-1079 cells, but not WITT-1 cells.
分子量
454.50
CAS号
1041852-85-0
运输条件
Room temperature in continental US; may vary elsewhere.