JI051 is a stabilizer for the Hes1-PHB2 interaction. JI051 interacts with a cancer-associated protein chaperone prohibitin 2 (PHB2), induces cell-cycle arrest by inhibiting the Notch downstream effector gene Hes1. Anti-cancer activity.
体外研究
JI051 causes G2/M cell-cycle arrest.
JI051 (0.1-10 µM, 24 hours) significantly inhibits cell proliferation of HEK293 cells, with an EC50 of 0.3 μM.
Cell Proliferation Assay
Cell Line:
HEK293 cells
Concentration:
0.1-10 µM
Incubation Time:
24 hours
Result:
Dose-dependently inhibits the proliferation of HEK293 cells at low concentrations.
分子式
C22H24N2O3
分子量
364.44
CAS号
2234281-75-3
运输条件
Room temperature in continental US; may vary elsewhere.