GLP-1R Agonist DMB - CAS:281209-71-0

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GLP-1R Agonist DMB

目录号 : KCM13119 CAS No. : 281209-71-0 纯度 : ≥98%

Data Sheet 产品使用指南

GLP-1R agonist DMB is an agonist of glucagon-like peptide 1 receptor (GLP-1R; K = 26.3 nM for the recombinant human receptor). It inhibits forskolin-induced cAMP accumulation in BHK cells expressing the recombinant human receptor with an EC value of 101 nM. GLP-1R (100 and 1,000 nM) increases insulin levels induced by D-(+)-glucose in pancreatic islets isolated from wild-type, but not Glp1r knockout, mice. It reduces fasting plasma glucose levels in mice when administered at a dose of 5 µmol/kg.

规格	价格	是否有货	数量
1mg		In-stock
5mg		In-stock
10mg		In-stock
25mg		In-stock

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生物活性

GLP-1R Agonist DMB is an effective GLP-1R agonist that exerts its activating effect by forming hydrogen bonds with the Tyr42, Cys71, and Ser84 residues of GLP-1R. GLP-1R Agonist DMB has the potential for research in metabolic diseases such as type 2 diabetes and obesity.

体外研究

GLP-1R Agonist DMB (100 nM, 1000 nM) can activate GLP-1 receptor-mediated cAMP production, with an EC₅₀ of 101 nM, but exhibits a self limiting effect at high concentrations .

GLP-1R Agonist DMB (100 nM) enhances the binding of GLP-1 to GLP-1 receptors and reduces the K_d value of GLP-1 (from 0.51 nM to 0.19 nM).

GLP-1R Agonist DMB (100 nM, 1000 nM) promotes glucose dependent insulin secretion in CD1 mouse islets, and this effect depends on the GLP-1 receptor. At concentrations of 100 nM and 1000 nM, GLP-1R Agonist DMB significantly enhances 10 mM glucose induced insulin secretion, similar to GLP-1, and this effect disappears in the islets of GLP-1 receptor knockout mice.

分子式

C₁₃H₁₅Cl₂N₃O₂S

分子量

348.25

CAS号

281209-71-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

2-8°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

DMSO :25 mg/mL (71.79 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.8715 mL	14.3575 mL	28.7150 mL
5 mM	0.5743 mL	2.8715 mL	5.7430 mL
10 mM	0.2872 mL	1.4358 mL	2.8715 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： ≥98%

Data Sheet

产品使用指南

暂无相关参考文献

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

体积

分子量*

重置计算

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

重置计算

动物实验计算换算器

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系客服为您提供正确的澄清溶液配方）

% DMSO

% Tween 80

% ddH₂O

% DMSO

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系客服）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

配置后的溶液总体积：

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

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The molarity calculator equation

The dilution calculator equation

动物实验计算换算器