Mazdutide (IBI-362; LY-3305677) 是一种长效合成胃泌酸调节素类似物。Mazdutide 也是胰高血糖素样肽 (GLP-1R) 与胰高血糖素受体 (GCGR) 的共激动剂。Mazdutide 结合人和小鼠 GCGR (Ki 值分别为 17.7 nM 和 15.9 nM) 和 GLP-1R (Ki 值分别为 28.6 nM 和 25.1 nM)。Mazdutide 刺激小鼠胰岛的胰岛素分泌 (EC50 为 5.2 nM)。Mazdutide 可用于肥胖和 2 型糖尿病 (T2D) 的研究。
| 生物活性 |
Mazdutide (IBI-362; LY-3305677) is a long-acting synthetic oxyntomodulin analog. Mazdutide is also a co-agonist of glucagon-like peptide (GLP-1R) and glucagon receptor (GCGR). Mazdutide binds human and mouse GCGR (Ki: 17.7 nM and 15.9 nM, respectively) and GLP-1R (Ki: 28.6 nM and 25.1 nM, respectively) and stimulates insulin secretion from mouse islets (EC50: 5.2 nM). Mazdutide is used in studies of obesity and type 2 diabetes (T2D). |
|---|---|
| 分子式 |
C210H322N46O67
|
| 分子量 |
4563.06
|
| CAS号 |
2259884-03-0
|
| 中文名称 |
Mazdutide
|
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
Store at -20˚C |
客服小K 
客服小K
Data Sheet
