LRE1 is a specific and allosteric inhibitor of soluble adenylyl cyclase.
IC50&Target
Adenylyl cyclase
体外研究
LRE1 binds to the bicarbonate activator binding site and inhibits soluble adenylyl cyclase (sAC) via a unique allosteric mechanism.
LRE1 prevents sAC-dependent processes in cellular and physiological systems and facilitates exploration of the therapeutic potential of sAC inhibition.
LRE1 (0.5-100 μM, 60 minutes ) inhibits sperm and mitochondrial functions of sAC.
Western Blot Analysis
Cell Line:
Mouse cauda sperm
Concentration:
0.5-100 µM
Incubation Time:
60 minutes
Result:
LRE1 inhibits sAC dependent sperm capacitation.
分子式
C12H13ClN4S
分子量
280.78
CAS号
1252362-53-0
运输条件
Room temperature in continental US; may vary elsewhere.