Dinactin - CAS:20261-85-2

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Dinactin (Synonyms:二活菌素)

目录号 : KCM12403 CAS No. : 20261-85-2 纯度 : ≥95%

Data Sheet 产品使用指南

Dinactin is a macrotetrolide antibiotic that acts as an ionophore for monovalent cations, such as K, NH, and Rb. It is commonly used to study membrane properties. Dinactin is a component of a macrotetralide-rich antifungal mixture produced by Streptomyces. Dinactin inhibits T-cell proliferation and cytokine production in vitro and reduces pulmonary eosinophilia in antigen-challenged mice.

规格	价格	是否有货	数量
1mg		In-stock
5mg		In-stock

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Tetravalent antibiotics B In-stock
Tetravalent antibiotics A In-stock
Blasticidin S solution (10mg/mL) In-stock

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生物活性

Dinactin , an antibiotic ionophore produced by Streptomyces species, as an effective small molecule targeting Wnt/β-catenin signaling pathway in cancer cells. Dinactin shows marked inhibition of HCT-116 cell growth with an IC50 of 1.1 µM. Dinactin shows anti-proliferative activity against the cancer cells in apoptosis-independent manner. Dinactin is also an effective agent for the research of neuropathic pain.

体外研究

Dinactin (compound 1) shows antibacterial activity with MIC values of 1, 0.039, 0.019, 0.078, 0.078, 0.156, 0.156, 0.156, 0.156 μg/ml for M.tuberculosis(ATCC 25177), S. epidermidis(ATCC 12228), M. luteus(ATCC10240), S. aureus(ATCC 35923), E. faecalis(ATCC 51299), B. subtilis(ATCC 11774), E. coli(ATCC 10536), P. aeruginosa(ATCC 10145), K. pneumonia(ATCC BAA-2146) strain, respectively.
Dinactin (0-100 µM) shows antitumor activity with IC₅₀ values of 1.3, 1.1, 1.3, 1.5, 9.7, 80 µM for A549, HCT-116, T47D, MCF7, HepG2, HEK-293 cells, respectively.
Dinactin (0.5, 1, 2 µM; 24 h) induces morphological changes in a concentration dependent manner in HCT-116 cells.
inactin (0.5, 1, 2 µM; 24 h) effectively inhabits cell migration and invasion characteristics in HCT-116 cells.

分子式

C₄₂H₆₈O₁₂

分子量

764.98

CAS号

20261-85-2

中文名称

二活菌素

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

纯度： ≥95%

Data Sheet

产品使用指南

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注意：1. 首先保证母液是澄清的；
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Other Forms of Rapamycin:

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