博莱霉素 D1 选择性抗生素，无菌溶液 (100 mg/mL) 是一种已过滤除菌，可直接用于细胞培养的抗生素溶液。博莱霉素 D1 来源于轮枝链霉菌（Streptomyces verticillus），属于博莱霉素（Bleomycin）家族成员，是一种碱性、水溶性的、铜离子螯合的糖肽抗生素，对细菌、真菌、植物和哺乳动物细胞均有毒性。可用于筛选\维持培养携带 Sh ble 基因的稳定转染细胞株。
| 生物活性 |
Bleomycin D1 selective antibiotic, sterile solution (100 mg/mL) is a filtered and sterilized antibiotic solution that can be directly used for cell culture. Bleomycin D1 is derived from Streptomyces verticillus and belongs to the Bleomycin family. It is an alkaline, water-soluble, copper chelated glycopeptide antibiotic that is toxic to bacteria, fungi, plants, and mammalian cells. Can be used to screen/maintain stable transfected cell lines carrying the Sh ble gene in culture. |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
Solution, -20°C, 1 year, protect from light |
| 描述 |
Bleomycin D1 selective antibiotic, sterile solution (100 mg/mL) is a filtered and sterilized antibiotic solution that can be directly used for cell culture. Bleomycin D1 selective antibiotic is derived from Streptomyces verticillus, a member of the bleomycin family. It is an alkaline, water-soluble, copper chelated glycopeptide antibiotic that is toxic to bacteria, fungi, plants, and mammalian cells.
The Sh ble gene, derived from Streptococcus hindustanus, encodes a 14 kDa protein that selectively binds to Bleomycin D1 and prevents it from binding to cellular DNA, thereby making cells resistant to Bleomycin D1. Therefore, Bleomycin D1 selective antibiotics can be used to screen/maintain stable transfected cell lines carrying the Sh ble gene in culture.
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