博莱霉素溶液 (100 mg/mL) 是一种已过滤除菌 ，可直接用于动物实验及细胞培养实 验即用型无菌溶液。本品主要成分为博来霉素 A2/B2，是一种 DNA 损伤剂，通过抑制 DNA 合成发挥抗肿瘤及细胞毒性作用,是构建肺纤维化动物模型最常用的诱导剂。
| 生物活性 |
Bleomycin solution (100 mg/mL) is a sterile solution that has been filtered and sterilized, and can be directly used for animal experiments and cell culture experiments. The main ingredient of this product is bleomycin A2/B2, which is a DNA damaging agent that exerts anti-tumor and cytotoxic effects by inhibiting DNA synthesis. It is the most commonly used inducer for constructing animal models of pulmonary fibrosis. |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
Solution, -20°C, 1 month, protect from light, Avoid repeated freeze-thaw cycles |
| 描述 |
Bleomycin D1 selective antibiotic, sterile solution (100 mg/mL) is a filtered and sterilized antibiotic solution that can be directly used for cell culture. Bleomycin D1 selective antibiotic is derived from Streptomyces verticillus, a member of the bleomycin family. It is an alkaline, water-soluble, copper chelated glycopeptide antibiotic that is toxic to bacteria, fungi, plants, and mammalian cells.
The Sh ble gene, derived from Streptococcus hindustanus, encodes a 14 kDa protein that selectively binds to Bleomycin D1 and prevents it from binding to cellular DNA, thereby making cells resistant to Bleomycin D1. Therefore, Bleomycin D1 selective antibiotics can be used to screen/maintain stable transfected cell lines carrying the Sh ble gene in culture.
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