BXL-628 - CAS:199798-84-0

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BXL-628 (Synonyms:艾洛骨化醇; Elocalcitol; Ro-26-9228)

目录号 : KCM12352 CAS No. : 199798-84-0 纯度 : ≥98%

Data Sheet SDS 产品使用指南

BXL-628 is an analog of vitamin D that has diverse biological activities. It increases death of androgen-stimulated human benign prostatic hyperplasia (BPH) cells via induction of apoptosis in a dose-dependent manner. In vivo, BXL-628 completely inhibits androgen-stimulated prostate overgrowth in a rat model of BPH. It reduces expression of IL-13 and IgE/mast cell-derived protease 1 (MMCP1) and decreases edema and leukocyte infiltration in the bladder wall in a mouse model of allergen-induced interstitial cystitis. BXL-628 also reduces the number of adherent endometrial stromal cells and decreases the total weight of endometrial lesions in a mouse model of endometriosis.

规格	价格	是否有货	数量
1mg		In-stock
5mg		In-stock

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生物活性

BXL-628, a vitamin D analogue, is a selective, orally active vitamin D receptor (VDR) agonist. BXL-628shows anti-inflammatory activity. BXL-628 inhibits growth of prostate cancer cells.

体外研究

BXL-628 (0.00-10 nM; 24-48 hours) can inhibit the proliferation and invasion of DU145 cells.
BXL-628 (10 nM; 8 hours) can inhibit KGFR autophosphorylation and downstream PI3K/AKT activation.

Cell Proliferation Assay

Cell Line:	DU145 cells
Concentration:	0.001 nM, 0.01 nM, 0.1 nM, 1 nM, 10 nM
Incubation Time:	48 hours
Result:	Inhibited dose dependently DU145 cell proliferation with an IC50 of 22.1 pM.

Cell Invasion Assay

Cell Line:	DU145 cells
Concentration:	10 μM
Incubation Time:	24 hours
Result:	Was able to inhibit invasion of DU145 cells.

Western Blot Analysis

Cell Line:	DU145 cells
Concentration:	10 μM
Incubation Time:	8 hours
Result:	Suppressed KGFR autotransphosphorylation and downstream PI3K/AKT activation.

体内研究

BXL-628 (100 μg/kg; oral administration; Once a day; Lasting for 14-28 days, it can inhibit the development of lesions in mouse models of endometriosis and have a protective effect on the implantation and organization of transplanted endometrial tissue.

Animal Model:	Adult Balb/c female mice was induced by injection of syngeneic endometrial tissue fragments.
Dosage:	100 μg/kg
Administration:	p.o.; once a day; for 14-28 days
Result:	Was able to reduce total lesion weight up to 70% upon. Was shown to reduce the capacity of mouse endometrial cells to adhere to collagen. Inhibited macrophage recruitment and inflammatory cytokine secretion.

分子式

C₂₉H₄₃FO₂

分子量

442.65

CAS号

199798-84-0

中文名称

艾洛骨化醇;2-(甲硫基)噻唑啉

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

DMSO: 30 mg/mL (67.77 mM; Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.2591 mL	11.2956 mL	22.5912 mL
5 mM	0.4518 mL	2.2591 mL	4.5182 mL
10 mM	0.2259 mL	1.1296 mL	2.2591 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： ≥98%

Data Sheet

SDS

产品使用指南

Marchiani S, et al. The vitamin D analogue BXL-628 inhibits growth factor-stimulated proliferation and invasion of DU145 prostate cancer cells. J Cancer Res Clin Oncol. 2006 Jun;132(6):408-16.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

体积

分子量*

重置计算

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

重置计算

动物实验计算换算器

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系客服为您提供正确的澄清溶液配方）

% DMSO

% Tween 80

% ddH₂O

% DMSO

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系客服）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

配置后的溶液总体积：

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

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The molarity calculator equation

The dilution calculator equation

动物实验计算换算器