N-acetyl-D-Leucine - CAS:19764-30-8

您当前的位置：

N-acetyl-D-Leucine (Synonyms:N-乙酰-D-亮氨酸;N-Acetyl-R-leucine)

目录号 : KCM12332 CAS No. : 19764-30-8 纯度 : ≥95%

Data Sheet SDS 产品使用指南

N-acetyl-D-Leucine is a derivative of D-leucine and a substrate for various enzymes in the amidohydrolase superfamily. It has been used to characterize the function of amidohydrolase enzymes from B. bronchiseptica, S. coelicolor, and G. oxydans.

规格	价格	是否有货	数量
10 mM * 1 mL in DMSO		In-stock
100g		In-stock
500g		In-stock

加入购物车大包装询价

Other Forms of Rapamycin:

AZD0095 In-stock
MCT1-IN-3 In-stock
N-acetyl-D-Leucine In-stock
MCT1-IN-2 In-stock
7ACC1 In-stock

KKL Med 的所有产品和服务仅用于科学研究，不能被用于人体，兽医，我们也不向个人提供产品和服务。

生物活性

N-acetyl-D-Leucine is an amino-protecting group N-substituted chiral amino acid. N-acetyl-D-Leucine is a PepT1 and MCT1 inhibitor with IC50 of 0.74 and 11 mM, respectively. N-acetyl-D-Leucine can be used for LysoTracker signaling studies.

体外研究

N-acetyl-D-Leucine is not a substrate of LAT1 and PepT1, but rather an inhibitor of PepT1 with an IC50 of 0.74 mM.
N-acetyl-D-Leucine is a substrate of MCT1 with a Km of 1.0 mM and also an inhibitor of MCT1, with an IC50 of 11 mM.
N-acetyl-D-Leucine (1-5 mM; 7 days) did not show a significant dose-dependent effect on LysoTracker signals in NPC1-deficient Chinese hamster ovary cells, but a statistically significant effect was observed at higher concentrations (5 mM).

体内研究

N-acetyl-D-Leucine (24 mg per rat; intravenous injection; once daily) had no significant effect on the compensation and postural imbalance scores of nystagmus in rats.

分子式

C₈H₁₅NO₃

分子量

173.21

CAS号

19764-30-8

中文名称

N-乙酰-D-亮氨酸

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO: 100 mg/mL (577.33 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	5.7733 mL	28.8667 mL	57.7334 mL
5 mM	1.1547 mL	5.7733 mL	11.5467 mL
10 mM	0.5773 mL	2.8867 mL	5.7733 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： ≥95%

Data Sheet

SDS

产品使用指南

Churchill GC, et al. Acetylation turns leucine into a drug by membrane transporter switching. Sci Rep. 2021 Aug 4;11(1):15812.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

体积

分子量*

重置计算

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

重置计算

动物实验计算换算器

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系客服为您提供正确的澄清溶液配方）

% DMSO

% Tween 80

% ddH₂O

% DMSO

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系客服）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

配置后的溶液总体积：

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

Other Forms of Rapamycin:

KKL 顾客使用本产品发表的 0 篇科研文献

The molarity calculator equation

The dilution calculator equation

动物实验计算换算器