Apoptolidin is an apoptosis inducer originally isolated from Nocardiopsis bacteria. It inhibits the mitochondrial FF ATPase (K = 4-5 µM). Apoptolidin selectively kills transformed glial cells without significantly affecting untransformed cells. It also has antibiotic and antifungal actions.
Apoptolidin is a polyketide isolated from Nocardiopsis bacteria. Apoptolidin is a selective mitochondrial F1FO ATPase inhibitor. Apoptolidin is an apoptosis inducer and induces apoptotic cell death in cells transformed with the adenovirus type 12 oncogenes including ElA (IC50=10-17 ng/ml) but not in normal cells.
体外研究
Apoptolidin has cytotoxicity against normal and transformed cells, it against RG-E1A-7,RG-E1A19K-2, RG-E1A54K-9, RG-E1-4 and Adl2-3Y1 with IC50 values of 11 ng/ml,10 ng/ml,13 ng/ml, 10 ng/ml and 17 ng/ml, respectively.
分子式
C58H96O21
分子量
1129.37
CAS号
194874-06-1
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder
-20°C
3 years
In solvent
-80°C
6 months
-20°C
1 month
溶解性数据
DMSO : 1 mg/mL (0.89 mM; Need ultrasonic and warming)