Cortistatin-29 (rat) (trifluoroacetate salt) (Synonyms:Cortistatin-29 (rat))
目录号 : KCM12101 CAS No. : 1815618-17-7 纯度 : ≥95%
Cortistatin-29 is a neuropeptide that is structurally similar to somatostatin-28. It is produced by cleavage of preprocortistatin to procortistatin, which is cleaved at dibasic amino acids to form cortistatin-29 and cortistatin-14 as well as other partial cleavage products. Cortistatin mRNA is expressed in the human brain and in interneurons of the rat hippocampus and cerebral cortex. Cortistatin-29 binds to somatostatin (SST) receptors with IC values of 2.8, 7.1, 0.2, 3, and 13.7 nM for SST, respectively. Cortistatin-29 is found at similar levels as cortistatin-14 in mouse AtT20 cells but is secreted at a lower level. Cortistatin-29 corresponds to residues 85-112 of the rat peptide sequence.
规格 价格 是否有货 数量
500μg
In-stock

Other Forms of Rapamycin:

KKL Med 的所有产品和服务仅用于科学研究,不能被用于人体,兽医,我们也不向个人提供产品和服务。
生物活性

Cortistatin-29 (rat) (trifluoroacetate salt) is a neuropeptide. Cortistatin-29 (rat) (trifluoroacetate salt) alleviates neuropathic pain. Cortistatin-29 (rat) (trifluoroacetate salt) binds all somatostatin (SS) receptor subtypes with high affinity and shows IC50 values of 2.8 nM, 7.1 nM, 0.2 nM, 3.0 nM, 13.7 nM for SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, respectively. Cortistatin-29 (rat) (trifluoroacetate salt) shows anti-fibrotic effects

体内研究

Cortistatin 29 (1-2 µg) can alleviate chronic neuropathic pain in mice.
Cortistatin 29 (1 nmol/mouse; Intraperitoneal injection; Three times a week, it showed anti fibrotic effects in mice.

 

Animal Model: 20-24 g body weight, 8-12 weeks-old mice
Dosage: 1 µg in 20 µL for s.c.; 2 µg in 200 µL for i.p.; 20 ng in 10 µL for i.t.
Administration: Every other day for 12 days
Result: Ameliorated hyperalgesia and allodynia, regulated the nerve damageinduced hypersensitization of primary nociceptors, inhibited neuroinflammatory responses, and enhanced the production of neurotrophic factors both at the peripheral and central levels.
 
 
分子式
C161H240N46O41S2.XCF3COOH
分子量
3540.04
CAS号
1815618-17-7
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
暂无相关参考文献
The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
动物实验计算换算器
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系客服为您提供正确的澄清溶液配方)
+
+
+

计算结果:

工作液浓度: mg/ml;

DMSO母液配制方法: mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,

体内配方配制方法:取 μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL ddH2O,混匀澄清。

配置后的溶液总体积:

1. 首先保证母液是澄清的;
           2. 一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。