(R)-Gyramide A is a bacterial DNA gyrase inhibitor that disrupts supercoiling activity with an IC value of 3.3 µM. It does not affect the closely related enzyme topoisomerase IV. (R)-Gyramide A demonstrates antibacterial activity against E. coli, P. aeruginosa, and S. enterica (MICs range from 10-80 µM).
(R)-Gyramide A (hydrochloride) is a bacterial DNA gyrase inhibitor that disrupts supercoiling activity with an IC50 value of 3.3 µM. (R)-Gyramide A (hydrochloride) demonstrates antibacterial activity against E. coli, P. aeruginosa, and S. enterica (MICs of 10-80 µM). (R)-Gyramide A (hydrochloride) does not affect the closely related enzyme topoisomerase IV.
分子式
C21H27FN2O3S.HCl
分子量
442.98
CAS号
1793050-70-0
运输条件
Room temperature in continental US; may vary elsewhere.