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ML-396 (Synonyms:VU 0422288)
目录号 : KCM11835 CAS No. : 1630936-95-6 纯度 : ≥98%
Data Sheet 产品使用指南
ML-396 is a positive allosteric modulator of group III metabotropic glutamate receptors (mGluRs) with EC values of 108, 146, and 128 nM for mGluR4, mGluR7, and mGluR8, respectively, in calcium mobilization assays. ML-396 potentiates LSP4-2022-induced reductions in paired-pulse field excitatory post synaptic potential (fEPSP) slopes in mouse hippocampal slices. In vivo, ML-396 (30 mg/kg) restores hippocampal long-term potentiation, improves novel object recognition, contextual fear learning, and social memory, and decreases sleep apneas in the Mecp2 mouse model of Rett syndrome.
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分子式
C17H11Cl2N3O2
分子量
360.19366
CAS号
1630936-95-6
中文名称
VU 0422288
储存方式
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
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The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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