(-)-L-threo-PDMP (hydrochloride) - CAS:161491-04-9

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(-)-L-threo-PDMP (hydrochloride)

目录号 : KCM11784 CAS No. : 161491-04-9 纯度 : ≥98%

Data Sheet 产品使用指南

(–)-L-threo-PDMP is a ceramide analog and one of the four possible stereoisomers of PDMP . L-threo-PDMP is an enhancer of ganglioside biosynthesis. It increases glucosylceramide synthase activity by 4 and 8% when used at concentrations of 5 and 2.5 µM, respectively, in an enzyme assay. L-threo-PDMP increases the activity of ganglioside GM, GD, and GQ synthases and increases the levels of glucosylceramide, lactosylceramide, and ganglioside GM in B16 melanoma cells. It inhibits the growth of MCF-7, MDA-MB-468, SK-BR-3 cells with IC values of 4, 7, and 6 µM, respectively. L-threo-PDMP increases neurite outgrowth and synapse formation in vitro and improves retention of a long-term memory learned prior to forebrain ischemia in rats when administered following ischemia at a dose of 40 mg/kg per day. The L-threo-PDMP isomer is the glucosylceramide synthetase stimulatory component of DL-threo-PDMP , while D-threo-PDMP is the inhibitory component.

规格	价格	是否有货
1mg	¥1638.00	In-stock
5mg	¥6552.00	In-stock
10mg	¥12285.00	In-stock

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生物活性

(−)-L-threo-PDMP hydrochloride is the hydrochloride form of (−)-L-threo-PDMP. L-threo-PDMP is a glucosylceramide synthase (GCS) inhibitor. L-threo-PDMP stimulates the proliferation of cultured aortic smooth muscle cells, and that increases the level of LacCer in B16 melanoma cells.

分子式

C₂₃H₃₈N₂O₃^.HCl

分子量

427.02

CAS号

161491-04-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

纯度： ≥98%

Data Sheet

产品使用指南

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系客服）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

配置后的溶液总体积：

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

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The molarity calculator equation

The dilution calculator equation

动物实验计算换算器