Orexin receptors R1 (OX1R) and OX2R mediate the action of the neuropeptides orexin A and orexin B. TCX-OX2-29 is an antagonist of OX2R (pK = 7.5) that exhibits >250-fold selectivity for hOX2R compared with hOX1R (ICs = 40 nM and >10,000 nM, respectively). It blocks the inhibitory action of orexin A on forskolin-induced cAMP formation.
TCS-OX2-29 (hydrochloride) is a potent, high affinities and selective orexin-2 receptor (OX2R) antagonist with an IC50 value of 40 nM and a pKI value of 7.5. TCS-OX2-29 displays ~250-fold selectivity for OX2 over OX1.
分子式
C23H31N3O3.HCl
分子量
433.97
CAS号
1610882-30-8
中文名称
TCS-OX 2-29
运输条件
Room temperature in continental US; may vary elsewhere.