AG-041R
目录号 : KCM11761 CAS No. : 159883-95-1 纯度 : ≥98%
The peptide hormone gastrin acts through G protein-coupled cholecystokinin-2 (CCK) receptors to regulate cell proliferation, differentiation, apoptosis, and gene expression of gastrointestinal cells and exerts trophic effects on a number of gastric cancer cell lines. AG-041R is a potent gastrin/CCK receptor antagonist that exhibits selective binding for CCK compared to CCK AG-041R inhibits gastrin-evoked secretion of pancreastatin (IC = 2.2 nM) as well as gastrin-induced histamine release and cell growth of Mastomys ECL carcinoid tumor cells. AG-041R (1 µM) exhibits synergistic inhibitory effects on the cell viability of human gastric cancer cells when administered in combination with the selective COX-2 inhibitor NS-398 at 10 µM.
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1mg
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5mg
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10mg
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50mg
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Other Forms of Rapamycin:

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生物活性

AG-041R is a potent and selective CCK2 Receptor/Gastrin antagonist. AG-041R inhibits gastrin-evoked secretion of pancreastatin with an IC50 of 2.2 nM. AG-041R inhibits cell growth of Mastomys ECL carcinoid tumor cells.

分子式
C31H36N4O5
分子量
544.7
CAS号
159883-95-1
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
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