4-Epianhydrochlortetracycline is a derivative of tetracycline . It inhibits matrix metalloproteinase-9 (MMP-9) activity in a dose-dependent manner in an assay for collagen degradation. 4-Epianhydrochlortetracycline also completely inhibits neutrophil-derived MMP-9 degradation of denatured collagen at a concentration of 500 μg/ml. Unlike tetracycline, 4-epianhydrochlortetracycline lacks antibiotic activity.
4-Epianhydrochlortetracycline (hydrochloride) is an inhibitor of matrix metalloproteinases (MMPs), particularly gelatinase B (Gelatinase B, EC 3.4.24.35), with inhibition rates of 100% at 500 μg/mL, 70% at 125 μg/mL, and 40% at 31 μg/mL. 4-Epianhydrochlortetracycline (hydrochloride) is promising for research in chronic inflammatory diseases.
分子式
C22H21ClN2O7.HCl
分子量
497.33
CAS号
158018-53-2
中文名称
4-差向四环素盐酸盐
运输条件
Room temperature in continental US; may vary elsewhere.