6'-Sialyllactose (sodium salt) - CAS:157574-76-0

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6'-Sialyllactose (sodium salt) (Synonyms:6’-唾液乳糖钠盐)

目录号 : KCM11724 CAS No. : 157574-76-0 纯度 : ≥98%

Data Sheet SDS 产品使用指南

6'-Sialyllactose consists of the monosaccharide N-acetylneuraminic acid linked to the galactosyl subunit of lactose at the 6 position. This connection is at the 3 position in the related compound, 3’-sialyllactose . Both are major milk oligosaccharides that avidly bind several viral strains, including strains of influenza, HIV-1, reovirus, and polyomavirus. These compounds can be used to differentiate and characterize the binding domains of viruses that recognize N-acetylneuraminic acid-capped cell surface receptors. They are also used as analytical reference standards for quantification in samples such as milk or colostrum.

规格	价格	是否有货	数量
5mg		In-stock
10mg		In-stock
50mg		In-stock

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生物活性

6'-Sialyllactose (sodium salt) promotes the growth of beneficial bacteria (such as Bifidobacterium and lactobacillus) and inhibits the proliferation of harmful bacteria. 6'-Sialyllactose (sodium salt) exhibits anti-inflammatory and anti-angiogenic activities. 6'-Sialyllactose (sodium salt) promotes the muscle health.

体外研究

6 '- Siallylactose (sodium salt) (0-50 μM, 24 h) inhibits Dihydrotestosterone induced HUVEC proliferation, tubular structure formation, and activation of VEGFR-2 related Akt-ERK signaling pathway.

Western Blot Analysis

Cell Line:

HUVEC

Concentration:

0-50 μM

Incubation Time:

24 hours

Result:

Downregulated levels of p-Akt and p-ERK.

体内研究

6 '- Dialyllactose (sodium salt) (5% added to mouse die, 2 weeks) can alleviate the anxiety like behavior of mice, and regulate the composition of flora in the model of social disorder (SDR) stress mice.
6'-Sialyllactose (sodium salt) (100 mg/kg, po, once daily, 5 times a week for 12 weeks) It can increase the muscle mass and strength of mice, thereby improving exercise endurance.

Animal Model:	SDR-stressed mouse model
Dosage:	5% added to mouse diet
Administration:	po, 2 weeks
Result:	Reduced the anxiety-like behavior in open field tests. Maintained the number of DCX-positive cells in the hippocampus.

Animal Model:	C57BL/6J mouse models
Dosage:	100 mg/kg
Administration:	po, once daily, 5 times a week for 12 weeks
Result:	Increased the mouse running distance. Increased the absolute weight of gastrocnemius and soleus muscles.

分子式

C₂₃H₃₈NO₁₉^.Na

分子量

655.53

CAS号

157574-76-0

中文名称

6’-唾液乳糖钠盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

2-8°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

H2O : 100 mg/mL (152.55 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.5255 mL	7.6274 mL	15.2548 mL
5 mM	0.3051 mL	1.5255 mL	3.0510 mL
10 mM	0.1525 mL	0.7627 mL	1.5255 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： PBS

Solubility: 12.5 mg/mL (19.07 mM); Clear solution; Need ultrasonic

纯度： ≥98%

Data Sheet

SDS

产品使用指南

MariarosariaMarotta, et al. The predominant milk oligosaccharide 6′-sialyllactose reduces the internalisation of Pseudomonas aeruginosa in human pneumocytes. Journal of Functional Foods Volume 6, January 2014, Pages 367-373.

Tarr AJ, et al., The prebiotics 3'Sialyllactose and 6'Sialyllactose diminish stressor-induced anxiety-like behavior and colonic microbiota alterations: Evidence for effects on the gut-brain axis. Brain Behav Immun. 2015 Nov;50:166-177.

Park EJ, et al., 6'-Sialyllactose Enhances Exercise Performance via Increased Muscle Mass and Strength. Nutrients. 2024 Aug 7;16(16):2600.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

体积

分子量*

重置计算

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

重置计算

动物实验计算换算器

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系客服为您提供正确的澄清溶液配方）

% DMSO

% Tween 80

% ddH₂O

% DMSO

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系客服）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

配置后的溶液总体积：

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

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The molarity calculator equation

The dilution calculator equation

动物实验计算换算器