TAN 1364B (Synonyms:(Rac)-RK-682)
目录号 : KCM11652 CAS No. : 154639-24-4 纯度 : ≥95%
TAN 1364B is a protein tyrosine phosphatase (PTP) inhibitor and the racemic and monomeric form of RK-682 . TAN 1364B inhibits the activity of the PTPs LMW-PTP, CDC25B, and PTP1B (ICs = 8.6, 12.4, and 0.7 µM, respectively), but the inhibitory activity against LMW-PTP and CDC25B is blocked in the presence of magnesium. TAN 1364B forms aggregates in solution and binds to both the PTP binding site and to protein surfaces.
规格 价格 是否有货 数量
500μg
In-stock
2.5mg
In-stock

Other Forms of Rapamycin:

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生物活性

TAN 1364B ((Rac)-RK-682)a racemate of RK-682, is a protein tyrosine phosphatases (PTPases) inhibitor. (Rac)-RK-682 inhibits protein tyrosine phosphatase 1B (PTP-1B), low molecular weight protein tyrosine phosphatases (LMW-PTP), and cell division cycle 25B (CDC-25B) with IC50s of 8.6 μM, 12.4 μM, and 0.7 μM, respectively.

IC50&Target

IC50: 8.6 μM (PTP-1B), 12.4 μM (LMW-PTP), and 0.7 μM (CDC-25B)

分子式
C21H36O5
分子量
368.51
CAS号
154639-24-4
中文名称
抗生素RK-682
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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