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(E/Z)-GO289 is a potent and selective casein kinase 2 (CK2) inhibitor (IC₅₀=7 nM). (E/Z)-GO289 strongly lengthens circadian period. (E/Z)-GO289 exhibits cell type–dependent inhibition of cancer cell growth that correlated with cellular clock function.

(E/Z)-GO289 is a potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth.(E/Z)-GO289 shows an IC₅₀ of 13 μM for PIM2 and is >1000 times higher than that for CK2.
(E/Z)-GO289 (3-9 μM; 2 days) strongly inhibits Caki-2, A498, and 769-P cells.
(E/Z)-GO289 enables manipulation of clock protein phosphorylation and cancer cell growth.

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