1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects. 1V209 can be conjugated with various polysaccharides to improve its water solubility, and enhance its efficacy, and maintain low toxicity.
体外研究
1V209 (0.1-10 μM) treatment significantly stimulates TNFα production in RAW246.7 cells.
1V209 (18 hours) treatment increases IL-6 production comparain bone marrow derived dendritic cells.
体内研究
The intravenous (IV) administration of the formulation to mice bearing 4T1 breast cancer tumors results in nanoparticle accumulation in tumors, reduction in primary tumor growth, and inhibition of lung metastases, as compared to saline-treated animals. Mice administered 1V209 experience significantly increases plasma levels of proinflammatory cytokines IL-6, IP-10, and MCP-1 at 2 h following IV administration.
分子式
C16H17N5O5
分子量
359.34
CAS号
1062444-54-5
运输条件
Room temperature in continental US; may vary elsewhere.