HA-100 is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. HA-100 also used as a ROCK inhibitor.
IC50&Target
PKC
12 μM (IC50)
PKG
4 μM (IC50)
PKA
8 μM (IC50)
MLCK
240 μM (IC50)
PKC
6.5 μM (Ki)
MLCK
61 μM (Ki)
体外研究
HA-100 inhibits MLC-kinase and PKC competitively with respect to ATP, with Kis of 61 and 6.5 μM, respectively.
分子式
C13H15N3O2S
分子量
277.34
CAS号
84468-24-6
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder
-20°C
3 years
4°C
2 years
In solvent
-80°C
6 months
-20°C
1 month
溶解性数据
In Vitro:
DMSO : 150 mg/mL (540.85 mM; Need ultrasonic and warming)