DM3-SMe 是一种美登素衍生物，是一种微管蛋白 (tubulin) 抑制剂，是一种抗体偶联药物 (ADCs) 的细胞毒性部分，可通过二硫键或稳定的硫醚键与抗体连接。DM3-SMe 在体外显示出高度的细胞毒性活性，IC50 为 0.0011 nM。
| 生物活性 |
DM3-SMe is a maytansine derivative and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM3-SMe shows highly cytotoxic activity in vitro with an IC50 of 0.0011 nM. |
|---|---|
| 分子式 |
C38H54ClN3O10S2
|
| 分子量 |
812.43
|
| CAS号 |
796073-70-6
|
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
关注我们
获得KKL MED 最新资讯
咨询热线：
400-881-9290
Data Sheet