2-D08 is a cell permeable, mechanistically unique inhibitor of protein SUMOylation. 2-D08 also inhibits Axl with an IC50 of 0.49 nM.
IC50&Target
IC50: 0.49 nM (Axl)
体外研究
2-D08 inhibits sumoylation by preventing transfer of SUMO from the UBC9-SUMO thioester to the substrate. 2-D08 decreases the ratio of p-Axl to t-Axl in a dose-dependent manner. Suppression of Axl kinase activity by 2D08 disrupts the cytoskeleton and actin filaments with re-organization at cellular junctions.
分子式
C15H10O5
分子量
270.24
CAS号
144707-18-6
运输条件
Room temperature in continental US; may vary elsewhere.