ML359 is a potent, selctive and reversible inhibitor of protein disulfide isomerase (PDI), with an IC50 of 250 nM. ML359 can prevent thrombus formation in vivo.
IC50&Target
IC50: 250 nM (protein disulfide isomerase)
体外研究
ML359 shows no cytotoxicity in three human cell lines (HeLa, HEK293, and HepG2), and some activity in inhibiting platelet aggregation in vitro (25% inhibition at 30 µM).
体内研究
ML359 inhibits of thrombus formation in a mouse laser injury model.
分子式
C19H18N4O3
分子量
417.93
CAS号
1069858-99-6
运输条件
Room temperature in continental US; may vary elsewhere.